Sankhya: The Indian Journal of Statistics

1995, Volume 57, Series B, Pt. 2, pp. 252--276

INHALATION TOXICOLOGY : AWARENESS, IDENTIFIABILITY, STATISTICAL PERSPECTIVES AND RISK ASSESSMENT

By

PRANAB KUMAR SEN and BARRY H. MARGOLIN,  University of North Carolina at Chapel Hill

SUMMARY. We are susceptible to xenobiotic environmental toxicity effects through a complex combination of absorption, inhalation and ingestion. Based on our belief that inhalation is the primary industrial/occupational/environmental site of uptake toxins, we examine the basic awareness and identifiability issues through an interdisciplinary approach, raise the statistical perspectives , and discuss the assessment of this compound risk in a sound statistical manner.

AMS (1991) subject classification.  62P10, 92C60, 92D40.

Key words and phrases. Absorption, accelerated life testing, alveoli, asbestosis, automobile exhausts, bioassay, bio-equivalence, biologic markers, black lung disease, cancer, carcinogen, case study, censoring, clinical epidemiology, clinical trials, domestic study, ecology,  environmental pollutants, environmental smoking, field study, hazard, industrial waste(exhausts), ingestion, logistic regression, lung cancer, measurement errors, meta analysis,  molecular biology, mutagenesis, OSL, odds ratio, pooling of information, proportional hazard model, risk, semi-parametric model, smoking, toxicity, xenobbiotic effects.

Full paper (PDF).