Sankhya: The Indian Journal of Statistics

2007, Volume 69, Pt. 3, 405--424

A Robust Approach for Linkage Detection Using Pedigrees

Saonli Basu, University of Minnesota, Minneapolis, USA

SUMMARY. Allele sharing method or trait-model-free approach is a robust technique for linkage detection. In allele sharing method, the association between the joint inheritance of the trait and a set of markers in pedigrees is studied without modelling the trait. This paper aims at an efficient implementation of allele-sharing method for binary trait in multi-generation pedigrees that includes construction of a robust identity by descent measure, and the use of a computationally efficient testing procedure to test for linkage. Simulation studies demonstrate that the proposed method performs well on extended pedigrees and appears to outperform the existing allele-sharing approaches on moderate size pedigrees.

AMS (2000) subject classification. Primary 62P10.

Key words and phrases. Identity by descent, robust linkage analysis, permutation test.

Full paper (PDF)